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Australia’s only biomedical manufacturing site where CAR T-cells and other “living” cancer therapies can be made at commercial scale has expanded to meet future patient demand.
Federal Minister for Health and Aged Care, the Honourable Mark Butler MP, today toured and officially opened the expanded facility at Peter MacCallum Cancer Centre in Melbourne.
The works were completed as part of a $105 million project, announced in 2019, and which also includes construction of dedicated facilities for patients receiving these therapies at Peter Mac.
The funding included $80 million from the Federal Government, and the additional $25 million was contributed by Peter Mac and generous donors to the Peter MacCallum Cancer Foundation to advance cellular therapy research and patient care activities.
Minister Butler said each year more than 160,000 Australians were diagnosed with cancer and, among these, more than 19,000 would be diagnosed with blood cancer.
“It is inspiring to see how much these individualised cancer treatments, being developed and manufactured here in Melbourne, can change people’s lives,” Mr Butler says.
Operated by Cell Therapies Pty Ltd, and partner manufacturer for the Centre of Excellence in Cellular Immunotherapy at Peter Mac, the expanded GMP-grade facility:
- can make up to 2,000 CAR T-cell (or other cell or gene therapy) patient doses a year, up 400% from previous capacity
- has added more than 75 biomedical jobs, and is the nation’s largest trainer for cell therapy laboratory roles
- has 1,700 square metres of new, additional lab and clean room space.
Peter Mac Chief Executive Professor Shelley Dolan said completing the manufacturing expansion was a major step forward for cancer patients in Australia and the Asia Pacific. The dedicated patient facility will open later this year.
With the Federal Government’s support, we are delivering on our vision for a world-class cellular immunotherapy centre in Australia and based at Peter Mac,” Prof Dolan said.
“The expanded manufacturing site has the necessary scale to provide CAR T-cell and other emerging cellular therapies to a growing number of patients in Australia and our region, and to support the rapid advances in related clinical and discovery-based research.”
Director of the Centre of Excellence in Cellular Immunotherapy Professor Simon Harrison said: “CAR T-cell therapy represents the pinnacle of personalised medicine as it involves collecting a patient’s own immune cells, re-engineering these cells so they recognise cancer, and infusing these re-engineered cells back into the patient.”
“Cellular therapies are living treatments that persist and expand in the body, and this approach has revolutionised how we treat many aggressive blood cancers and there is great hope they will do the same for solid tumours in the future.”
Acting Chief Executive of Cell Therapies Pty Ltd, Associate Professor Dominic Wall said the pandemic and global unrest had demonstrated the vulnerability of global supply chains and the value of onshore manufacturing capability.
“These expanded facilities at Peter Mac are now on par with only a handful of sites globally and combined with a highly specialised workforce, mean we have the ability to make more of these cutting-edge treatments locally, rather than importing them, and to even export these products.”
Construction of the expanded manufacturing facilities and dedicated clinical unit has been ongoing within the Victorian Comprehensive Cancer Centre building, with support from Plenary Health, Honeywell Pty Ltd and building contractor Minicon Construction.
Contacts
For more info or to arrange an interview contact the Peter Mac Communications team on 0417 123 048.
About CAR T-cell therapy
A cornerstone of modern immunotherapy is CAR T-cell therapy. This is “living drug” that represents the ultimate in personalised medicine. A patient’s T cells are re-engineered with Chimeric Antigen Receptors (CARs), expanded in a lab and reinfused into the body to attack and kill the patient’s cancer cells. CAR T-cells are designed to persist within the patient’s body for as long as a tumour is present – it is therefore intended as a one-off treatment which can prevent relapse. CAR T-cell therapy offers hope to patients for whom all other therapies have failed – it is demonstrating curative potential in previously incurable cancers such as myeloma.
Find out more information on subsidized access to CAR T-cell therapy
About Cell Therapies Pty Ltd
Cell Therapies Pty Ltd (CTPL) is one of the most experienced commercial contract manufacturers of global cellular therapy products. Since 2003, CTPL has provided essential infrastructure and expertise for development and delivery of these products into international clinical trials and commercial markets. Its state-of-the-art GMP facility in Melbourne, Australia, holds licenses from the Australian and Japanese regulatory authorities, de-risking product supply for the Asia Pacific region and serving as a single access point for regional deployment of cellular therapies. CTPL is a fee-for-service organisation and provides a complete process development and GMP product supply service from translational studies through to commercial supply. Key relationships with the Peter MacCallum Cancer Centre enable access to emerging research and clinical expertise.
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We offer care that goes beyond treatment
Peter Mac has a wellbeing approach to care. We base this on a fundamental belief that the best cancer care treats the person and the disease. The Wellbeing Centre is a sanctuary for patients, their families and carers. It is a gathering place that is open, accepting and welcoming for all.
Cancer can be hard to deal with and we know that getting treatment is only part of it. You might have other challenges and need help with them. We offer many kinds of help for you, your loved ones, and your carers. Each resource can help you deal with how cancer affects your body, emotions and money.
The Victorian Adolescent and Young Adult Cancer Service is a team of health and other professionals who specialise in the care of young people aged 15 to 25. We work with you and your healthcare team to support you at all stages of the cancer journey, anywhere in Victoria.
You are a carer if you’re taking care of someone with cancer. You might be a family member, friend or neighbour. Our wonderful volunteer service is here to help to make things a little easier for you and the person you’re caring for. They offer a range of support, resources, and items to help you.
The Psychosocial Oncology Program is a multidisciplinary team. This includes clinical psychologists, social workers, PCLNs, and psychiatrists/psychiatric registrars. They assess patients at risk of mental health problems. They will also assess and treat those with current mental health problems.
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