This integrated program allows insight into fundamental aspects of cancer biology through the identification of novel tumour-suppressor and tumour-initiating genes. We explore the functional relationships between altered cancer genetics and aberrations to the cancer epigenome, and a deeper understanding of the molecular events that drive oncogenic signalling networks. These findings serve as a basis for extensive translation-based studies to determine the potential therapeutic benefit of interfering with or augmenting the activity of key proteins involved in these signalling networks through pharmacological intervention.