Associate Professor Kristin Brown is a Group Leader in the Cancer Biology and Therapeutics Program at the Peter MacCallum Cancer Centre and holds a joint appointment in the Department of Biochemistry and Pharmacology at the University of Melbourne. Following the award of her PhD from the University of Otago in 2009, Kristin completed postdoctoral training at Beth Israel Deaconess Medical Center/Harvard Medical School. Her research focused on oncogenic signalling pathways and mechanisms of therapy resistance in breast cancer (Nature, 2012 and Cell Reports, 2015). This included work demonstrating that therapy-induced reprogramming of cellular metabolism drives chemotherapy resistance (Cancer Discovery, 2017). In 2016, Kristin relocated to Australia to establish her research laboratory. Her laboratory uses a variety of biochemistry, molecular biology and cell biology techniques to investigate the fundamental mechanisms contributing to regulation of cellular metabolism, and the impact of aberrant cellular metabolism on tumour initiation and progression (Cancer Discovery, 2021, Developmental Cell, 2022 and PNAS, 2023). This fundamental knowledge is applied to the pre-clinical development of novel and more effective interventions for cancer therapy.