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The Robert Ramsay laboratory specialises in transcriptional control, stem cell biology and models of colorectal cancer (CRC), peroneal cancers (for example, anal and penile SCCs) and their metastasis. We were the first in... Read more

The research focuses on understanding how cells of the tumour microenvironment can contribute to the progression of cancer either by promoting resistance to existing drugs or through enhancing metastatic spread. We are using... Read more

Barrett’s oesophagus is a metaplasia, acquired as a consequence of chronic acid and bile reflux, where the normal squamous epithelium is replaced by an intestinal-type columnar epithelium. Clinically, Barrett’s oesophagus is... Read more

Cytotoxic lymphocytes recognise and kill cancerous and virus-infected cells through the cytotoxic granule exocytosis pathway. Cytotoxic granules store a pore-forming protein, perforin, and serine proteases, granzymes. Once... Read more

Recent breakthroughs in our understanding of anti-cancer immune responses has led to the development of an expanding generation of cancer immunotherapies, and a revolution in the treatment of cancer. Immunotherapies are designed... Read more

The Sherene Loi lab team is internationally recognised for their use of genomic and immunological approaches to understand mechanisms of breast cancer growth and drug resistance. The primary focus of the Sherene Loi lab is... Read more